Blue Ridge Data Science Institute  ("Bird's Eye")

From Noise to Inference

Computational science rooted in Appalachia — applied to health systems, environmental conservation, and public policy across the nation.

100+
Peer-reviewed publications
10+
Years of clinical informatics expertise
AI/ML · Biostatistics · Cohort Development · Model Deployment · Workflow Optimization
Core competency domains
Our Mission

To calmly transform chaotic real-world data and systems into flowing, nimble insights.

What We Do

Three pillars.
One mission.

BiRDSI applies rigorous computational science across three intersecting domains — each grounded in real-world data, each serving communities that matter.

Health & Clinical Data Science

Predictive modeling, epidemiology, biostatistics, and cost-effectiveness analysis applied to complex clinical questions. Specialty expertise in immunology, rare disease, and real-world evidence generation.

AI / ML Epidemiology Biostatistics Cost-effectiveness RWE

Appalachian Environment & Conservation

Data-driven analysis in defense of Appalachia's natural heritage — forests, waterways, and public lands. Quantitative evidence for conservation policy, land use decisions, and environmental advocacy.

Land use analysis Conservation Forest policy Climate data

Policy & Advocacy Analytics

Turning public data into public arguments. We build the quantitative case for policy positions — from federal land management rules to health equity legislation — giving advocates the evidence they need.

Policy modeling Public comment Impact analysis Data journalism
Blue Ridge Mountains, Virginia

Rooted in the Blue Ridge.
Reaching across health systems nationwide.

Forest, Virginia  ·  BiRDSI  ·  birdsi.org

Featured Case Study

The Roadless Area Rule — A Data Story

Appalachian Environment & Conservation

The 2001 Roadless Area Conservation Rule protected nearly 58.5 million acres of National Forest lands from road construction and resource extraction. Its proposed rescindment threatened one of the most significant conservation achievements in modern US history — including millions of acres of Appalachian forest critical to water quality, biodiversity, and community wellbeing.

BiRDSI conducted a quantitative analysis of the ecological, hydrological, and community impact of roadless area rescindment across Appalachian National Forest units — translating complex geospatial and environmental data into plain-language evidence for public comment and advocacy use.

The analysis drew on USDA Forest Service data, watershed delineation models, and community health metrics to build the quantitative case for roadless protection — the kind of rigorous, data-driven advocacy that turns a public comment into a compelling argument.

Figure 1 — Study Area: Inventoried Roadless Areas, Core Appalachian National Forests
GW&J 412k ac Mono. 180k ac Pisgah-N. 151k ac Cherokee 84k ac Allegheny Chatt. D. Boone PA WV VA KY NC TN GA TOTAL STUDY AREA 918,434 acres · 411 IRAs Inventoried Roadless Area Appalachian Ridge (schematic) N↑

Seven national forest groupings in the core southern and central Appalachians. Area symbols are proportional to inventoried roadless acreage. The George Washington & Jefferson (412k ac) and Monongahela (180k ac) contain the largest roadless areas; the Daniel Boone (3k ac) the least. Schematic only — not a legal boundary map.

Figure 2 — Cumulative Slope Distributions: Roadless vs. Harvested Land by Forest
75% 50% 25% 100% 0% Cumulative % of acres 0% 10% 20% 30% 40% 50% 60% 70% Slope (%) 35% slope 40% Roadless areas (by forest) Harvested since FY2001 Allegheny shown bold (gentlest)

Roadless land is steeper than harvested land in every forest, but harvest has occurred on steep ground in several. Since FY2001, 47% of harvested acres in Pisgah-Nantahala and 42% in Cherokee were above 35% slope — making steepness alone a weak predictor of what the agency has treated in practice. Allegheny shown bold; other forests stacked behind.

31%

Of Appalachian roadless acres classified as "likely operable" under the DEIS screen — 55% as "operable but complex" and only 14% as not operable.

454k

People served by surface-water intakes in watersheds containing Appalachian roadless land — directly at risk from increased sedimentation.

5×

Higher landslide density in roadless areas vs. other national forest land in the Hurricane Helene impact zone (0.48 vs. 0.10 per 1,000 acres).

Technical Summary

Key Findings from the Appalachian Roadless Analysis

⛰
Steep but accessible

61% of roadless acres exceed 35% slope, yet the DEIS operability screen classifies 86% as operable or complex — terrain alone does not protect most of this land.

🌲
Harvest on steep ground

Since FY2001, 47% of harvested acres in Pisgah-Nantahala and 42% in Cherokee were above 35% slope — making steepness a weak predictor of agency practice.

💧
Drinking water at risk

454,000 people are served by surface-water intakes in watersheds containing Appalachian roadless land. Tracing downstream reaches ~1.8 million served.

⚠️
Landslide hazard

Hurricane Helene landslide density was ~5× higher in roadless areas (0.48/1,000 ac) vs. other national forest land (0.10) — these are failure-prone slopes.

📊
Screen sensitivity

Shifting the DEIS operability thresholds by just 10 slope points moves the "likely operable" share from 20% to 42% — the method is highly sensitive to undisclosed inputs.

🔬
Fully reproducible

All code, derived tables, and figure scripts are openly archived. Running make_all.sh regenerates every number and figure from public source data.

Who We Are

Clinician. Scientist.
Appalachian.

NR
Dr. Nicholas L. Rider
Dr. Nicholas L. Rider, DO Founder & Principal Scientist

Dr. Rider is a physician-scientist, immunologist, and data scientist based in Forest, Virginia — in the shadow of the Blue Ridge Mountains he has spent his career studying and defending. He is a Professor at the Virginia Tech Carilion School of Medicine and founder of the CHILI Lab (Computational Human Immunology Lab and Innovation Hub).

BiRDSI emerged from a simple conviction: that the same rigorous computational tools used to understand rare disease and health systems can be turned toward the land, the water, and the communities of Appalachia. The mountains don't need poetry — they need data.

Zanshin Inference, LLC

BiRDSI's commercial consulting arm — providing health data science, AI/ML, epidemiology, and cost-effectiveness services to pharma, health systems, and public agencies. Zanshin (残心) — the calm, sustained awareness that follows action.

Professor, Health Systems & Implementation ScienceVirginia Tech Carilion School of Medicine
Director, CHILI LabComputational Human Immunology Lab and Innovation Hub
100+ peer-reviewed publicationsGoogle Scholar · MyNCBI · Experts@VT

Core Capabilities

Where we work

Six technical domains, applied across health, environment, and policy.

01

Artificial Intelligence in Health

Clinical NLP, EHR phenotyping, imaging informatics, and decision-support systems.

02

Machine Learning & Predictive Modeling

Gradient boosting, neural networks, and interpretable ML on complex real-world datasets.

03

Epidemiology & Population Health

Disease burden, disparities research, rare disease surveillance, and cohort development.

04

Biostatistics & Study Design

Survival analysis, Bayesian methods, causal inference, and regulatory-grade statistical analysis.

05

Cost-Effectiveness & Health Economics

Markov models, budget impact analysis, ICER, and payer-facing value evidence.

06

Geospatial & Environmental Analytics

Land use modeling, watershed analysis, and environmental impact quantification for policy advocacy.

Representative Work

Selected engagements

Across health, environment, and policy — a sample of BiRDSI's analytical work.

ML-based phenotyping of primary immunodeficiency from EHR data

Machine-learning pipeline identifying undiagnosed PI patients from structured and unstructured EHR data across a large integrated delivery network.

AI / ML

National burden of disease analysis for inborn errors of immunity

Population-level epidemiological analysis characterizing diagnosis delay, comorbidity burden, and geographic disparities in the US.

Epidemiology

Roadless Area Rule rescindment opposition analysis

Quantitative impact analysis of proposed National Forest roadless area rule rescindment across Appalachian forest units — built for public comment and conservation advocacy.

Conservation

Cost-effectiveness model for immunoglobulin replacement therapy

Decision-analytic Markov model comparing IgG administration routes from a US payer perspective; submitted to support formulary review.

Cost-effectiveness

Biostatistical consulting for rare disease clinical trial

End-to-end statistical design and analysis support for a Phase II IIT in rare immune-mediated disease, including SAP and interim analysis plan.

Biostatistics

Work With Us

Start a conversation

Whether you need a rigorous analysis, an expert voice, or a partner to build something new — we'd love to hear from you.

[email protected]
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CHILI Lab (Academic Site)

BiRDSI · Forest, Virginia
birdsi.org  ·  zanshininference.com